#3484 A NETWORK META-ANALYSIS COMPARING INTENSIVE GLYCEMIC CONTROL AND SGLT-2 INHIBITORS IN PREVENTING RENAL OUTCOMES

Abstract Background and Aims Type 2 diabetes (T2D) is one of the prominent causes for chronic kidney disease (CKD) leading to end-stage renal failure. Traditionally, prevention retardation CKD was attempted with effective glycemic blood pressure control. In recent times sodium glucose co-transporter inhibitors (SGLT-2is), glucagon-like peptide 1 receptor agonists (GLP1-RA), non-steroidal mineralocorticoid (MRA) have proved be excellent agents in preventing cardio-renal outcomes patients T2D, independent baseline SGLT-2is rank highest network meta-analysis-based scoring. We conducted this meta-analysis explore ranking intensive therapy comparison SGLT-2is, better understand present position traditional approach its relevance. Method A database search using Cochrane library identify relevant citations. Analysis RStudio (2022.07.1, Build 554). Using progression macroalbuminuria (ESKD) as interest, scoring performed comparing control (IGC) SGLT-2is. a frequentist P-score corroborated Surface Under Cumulative Ranking (SUCRA) Bayesian meta-analysis. Results pooled population 62,742 from twelve citations were included analysis. The risk bias used assess quality studies. IGC scored higher than far concerned while both (0.99 Vs 0.50) well SUCRA (0.97 0.52). similar trend also observed ESRD end point (0.84 0.65) (0.81 0.68) rankings favoring (Fig. 1). Conclusion importance achieving targets should emphasized recommendations same footing choice individual reno-protective agents.